Our Study Purpose

Centenarians (ages >100 yrs) and even more-so, semi-supercentenarians (ages 105-109 yrs) and supercentenarians (110+ yrs) are outliers not only for their exceptionally long lifespans, but also for their longer female fertility and marked delay of or escape from (resistance to) aging-related disability and morbidities such as Alzheimer’s disease, heart disease, stroke, diabetes and cancer. Their offspring also exhibit delayed morbidity and lower mortality compared to their birth cohort.

This initiative aims to integrate multi-omics data from centenarians and centenarian offspring (and controls) to identify protective profiles associated with exceptional longevity associated phenotypes and possible protection against Alzheimer’s disease. This project will also perform expanded tissue-specific, multi-omics analyses on at least 60 different mammalian species of varied life spans to identify potential factors contributing to long life span. iPSCs are developed from participants age 103+ years and lines are differentiated into hepatocyte and central nervous system cell lines that are then used for functional studies of resistance/resilience.