iPSC-based Modeling of Exceptional Longevity:

Understanding the Molecular and Functional Basis of Healthful Aging

For these studies, the Boston University and Boston Medical Center’s Center for Regenerative Medicine (CReM) is creating the first-of-its-kind library of
induced pluripotent stem cells (iPSCs) from centenarians. Harnessing this stem cell bank, investigators will have an unlimited resource of longevity-specific biomaterials and tissues to fuel the study of and develop novel therapeutics for aging-related disease.

In a second area of investigation, researchers are creating large numbers of iPSC-derived hepatocytes and neurons to functionally evaluate resiliency and/or response to stress in centenarian vs. control cells.


Co-Director of BU and BMC Center for Regenerative Medicine (CReM)

Integrative Analyses