Old Woman

Our Study Purpose

Centenarians (ages >100 yrs) and even more-so, semi-supercentenarians (ages 105-109 yrs) and supercentenarians (110+ yrs) are outliers not only for their exceptionally long lifespans, but also for their longer female fertility and marked delay of or escape from (resistance to) aging-related disability and morbidities such as Alzheimer’s disease, heart disease, stroke, diabetes and cancer. Their offspring also exhibit delayed morbidity and lower mortality compared to their birth cohort.

This initiative aims to integrate multi-omics data from centenarians and centenarian offspring (and controls) to identify protective profiles associated with exceptional longevity associated phenotypes and possible protection against Alzheimer’s disease. This project will also perform expanded tissue-specific, multi-omics analyses on at least 60 different mammalian species of varied life spans to identify potential factors contributing to long life span. iPSCs are developed from participants age 103+ years and lines are differentiated into hepatocyte and central nervous system cell lines that are then used for functional studies of resistance/resilience.

Words from Our Investigators

About Us

THOMAS T. PERLS, MD, MPH

Contact PI

Director of the
New England Centenarian Study,
Professor of Medicine at Boston University

Geriatrics, extreme longevity, genetics

PAOLA SEBASTIANI, PHD

Multiple PI

Director of Biostatistics, Epidemiology,
and Research Design at Tufts CTSI,
Director of Quantitative Methods and
Data Science at Tufts Medical Center

Bayesian modeling, genetics and genomics, machine learning

​NICHOLAS SCHORK, PHD

Contact PI

Professor and Director of the Quantitative Medicine and Systems Biology Division
at TGen

Quantitative translational biomedical science and integrated approaches to complex biological and medical problems

Profiles in Non-Human Species

Species Lifespan in Years

Learn More

Our Participants

13
Year

1928

16
Year

1931

30
Year

1945

38
Year

1953

44
Year

1959

61
Year

1976

68
Year

1983

79
Year

1994

107
Year

2022

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