Effect of longevity genetic variants on the molecular aging rate

Evidence that extreme human longevity is heritable is solid: extreme longevity clusters in families, and siblings of centenarians have a much better chance of living to extremely old ages compared to their generation. Genome-wide association studies (GWASs) of centenarians have identified genetic variants that associate with extreme human longevity, including the well-replicated association of APOE, FOXO3, and CDKN2A/CDKN2B.